Prognostic Implications of HER-2 Status in Steroid Receptor–Positive, Lymph Node–Negative Breast Carcinoma
نویسندگان
چکیده
منابع مشابه
Correlation of ER, PR and HER-2/Neu with other Prognostic Factors in Infiltrating Ductal Carcinoma of Breast
Background and Objectives: Breast cancer is the most common malignancy among women in the world. The aim of this study was to assess estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu of infiltrating ductal carcinoma (IDC) with tumor size, histologic grade, lymph node metastasis and age. Methods: This study was carried out on 300 tissue blocks ofpatients with ID...
متن کاملHER-3 expression in HER-2-amplified breast carcinoma
AIM OF THE STUDY To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). MATERIAL AND METHODS In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. RESULTS Higher HER-3 status if estimated b...
متن کاملCorrelation between the steroid receptor status and Her 2 neu amplification of primary breast carcinoma and lymph node metastases: a retrospective analysis.
Carcinoma of breast is a common cancer in women. Prognosis of breast carcinoma is assessed using steroid receptor status and Her 2 neu amplification. Steroid receptors, when present denotes a favourable clinical outcome and has also been used to determine whether a patient benefits from adjuvant therapy [1]. Her 2 neu amplification is associated with a poor prognosis [2]. Furthermore, Her 2 neu...
متن کاملcorrelation of er, pr and her-2/neu with other prognostic factors in infiltrating ductal carcinoma of breast
background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...
متن کاملPrognostic impact of phosphorylated HER-2 in HER-2+ primary breast cancer.
PURPOSE Tyrosine 1248 is one of the autophosphorylation sites of human epidermal growth factor receptor (HER)-2. We determined the prognostic value of the expression level of tyrosine 1248-phosphorylated HER-2 (pHER-2) in patients with HER-2(+) primary breast cancer using a reverse-phase protein array. PATIENTS AND METHODS The optimal cutoff value of pHER-2 for segregating disease-free surviv...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2007
ISSN: 0002-9173,1943-7722
DOI: 10.1309/fwheqx6hb9190lvy